I just came here cuz of FMA...XD you were the first reply to my translation post.
Basically, you'll have to stop looking down at the tablet. Get your hand-eye coordination to get used to the fact that you're drawing on the screen, not on the tablet itself, that might help with the guiding. Also, just try out some simple things first like shineko said--writing, doodling..etc.
The tablet is convenient, but not something that'll solve all your problems^^/
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Basically, you'll have to stop looking down at the tablet. Get your hand-eye coordination to get used to the fact that you're drawing on the screen, not on the tablet itself, that might help with the guiding. Also, just try out some simple things first like
The tablet is convenient, but not something that'll solve all your problems^^/